Lactoferrin Manufacturer

Product Details

1.Introduction

Lactoferrin Manufacturer is Pioneer Biotech. Lactoferrin (lactotransferrin), is a kind of iron binding glycoprotein which belongs to the transferrin family. Lactoferrin is high in colostrum and milk, which was discovered in breast milk by scientists MONTREUIJ and JOHANSONB in 1960. Subsequently, BAGGIN and other scientists found this protein in the body fluids and various cells of some organisms and began a lot of researches. In addition, studies have shown that lactoferrin has the functions of broad-spectrum antibacterial, anti-viral infection and immunity enhancing.

2.Functions

Lactoferrin is an iron binding glycoprotein in transferrin, which is concentrated in human and mammalian milk and various secretory fluids. However, the content in colostrum is the highest. A small amount of lactoferrin is also contained in mammalian mucosal surface, tear, saliva, leukocyte particles, pancreatic juice, bile and intestinal fluid. It has a wide range of functions, including sterilization, bacteriostasis, anti-virus, immune regulation, promoting iron absorption and other unique physiological functions.

2.1 Antibacterial

It has been determined that lactoferrin is a broad-spectrum bacteriostatic agent, which can inhibit Gram-negative bacteria requiring iron, such as coliform, Salmonella, etc; It can also inhibit Gram-positive bacteria. However, it basically does not inhibit bacteria with low iron demand, such as lactic acid bacteria.

2.2 Antiviral

Pioneer Biotech is the Lactoferrin Manufacturer. It is plays a great role in resisting viruses in the host, and can inhibit human immunodeficiency virus (HIV), cytomegalovirus, herpesvirus types 1 and 2, hepatitis C virus (HCV), influenza virus and so on.One explanation for the antiviral mechanism of lactoferrin is that lactoferrin can combine with virus and host cells, so as to block the combination between virus and host cells and protect the latter from the harm of virus.

2.3 Antioxidant

Excess oxygen free radicals in the body form lipid peroxide, which can damage cells and tissues. It is a sign of aging and disease. Lactoferrin can bind iron ions and block the lipid oxidation and survival transformation of oxygen free radicals caused by iron ions. All these can reduce the damage of free radicals to elastin in arterial wall, so as to prevent and treat atherosclerosis and coronary heart disease.

2.4 Regulate immune response

Lactoferrin can combine with lymphocytes, monocytes, macrophages and other cells to play a variety of functions. Lactoferrin can induce humoral immune response, promote lymphocyte proliferation, regulate bone marrow cell production and reduce inflammation. At the same time, lactoferrin can kill pathogens by stimulating neutrophils to produce peroxides. Lactoferrin can induce the proliferation of intestinal mucosal cells and spleen cells and promote the maturation of intestinal immune system.

2.5 Inhibit the development of cancer. 

Lactoferrin is an in vitro broad-spectrum antiviral substance of human and animal viruses based on DNA / RNA. Resistant to: herpes simplex virus type I and II, cytomegalovirus, human immune deficiency virus, hepatitis C virus, hantavirus, rotavirus, poliovirus type I, human respiratory syncytial virus and murine leukemia virus.

Reference: https://www.spandidos-publications.com/10.3892/ijo.2021.5265

2.6 Regulate iron absorption

As an iron fortifier, the absorption effect of lactoferrin is much better than that of ferric sulfate. Lactoferrin has the ability to bind and transport iron. It can release iron after reaching the human intestine, which can enhance the actual absorption and bioavailability of iron. 

2.7 Lactoferrin for the treatment of COVID‑19

Recently, American scientists have used artificial intelligence technology to screen dozens of drugs that can deal with COVID-19, including lactoferrin.

Reference: https://www.spandidos-publications.com/10.3892/etm.2020.9402

2.8 Other functions

Lactoferrin can prevent gastrointestinal tumors, such as colon cancer and gastric cancer, and inhibit tumor metastasis. In addition, lactoferrin can promote the growth of beneficial bacteria such as bifidobacteria and Lactobacillus in the intestine and inhibit harmful bacteria.

3.Applications

Lactoferrin Manufacturer is Pioneer Biotech. Lactoferrin's extensive biological functions determine that it can be used in cosmetics, food and health products, animal husbandry and other fields.

4.Flow Chart

5.Quality Standard of Lactoferrin

According to GB1903.17-2016

6.Method of Analysis of Lactoferrin

1. Method

Use HPLC instrument, detect the lactoferrin at 280nm with area normalization method.

2. Prepare of the material

2.1 Grade 1 water.

2.2 HPLC Acetonitrile.

2.3 0.9%NaCl solution

2.4 1% trifluoroacetic acid solution: take 1ml trifluoroacetic acid solution, dilute with grade 1 water to 100ml, go with 0.45μm filter membrane.

2.5 HPLC instrument with UV detector.

3. Chromatographic condition

3.1 The chromatographic column: 

Alltech prosphere C4 300A(150 mmx4.6 mm),

Alltech All-guardTM Guard(7.5mm x4.6mm), or same function column.

3.2 Detect wavelength: 280nm.

3.3 Flow rate: 1.0ml/min.

3.4 Column Temperature: 35°C.

3.5 Injection Volume: 50μl.

3.6 Gradient elution parameters.

4. Test steps

Take sample and lactoferrin standard reference 0.1g each, both add 10ml grade 1 water (or NaCl solution), and go through 0.45μm filter membrane, then we get the sample solution and the reference solution. Use 50μl each to test at 280nm, and make the same remaining time (about 10min). The main peak is the peak of Lactoferrin. Calculate all the peak area among the twice remaining time. The ratio of main peak area and all peak area is the lactoferrin assay out of the total protein.

7.Reference Chromatogram of Lactoferrin Reference Substance

8.Stability and Safety
Stability:
Stable under proper conditions(room temperature). Stability Data Sheet is available upon your request.
Safety:
According to GARS(Generally Recognized As Safe) Notice of US, it is safe for human consumption.

9.Customer Comments

We have shops on Alibaba, Chemicalbook and LookChem, through high quality products and unreserved services, we have gained a lot of favourable comments.

10.Our Certificates

Over the years, we have been committed to the product manufacture optimization and quality system establishment. We've set up the quality management system and obtained certificates of it.

11.Our Clients

We've established business relationship with Abbott, Unilever, Shiseido, KANS and SIMM, etc.

12.Exhibitions

We often attend international exhibitions, including CPhI, FIC, API, Vitafoods, SupplesideWest.

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